DIRECT AND INDIRECT INACTIVATION OF BACTERIOPHAGE T6 CONTAINING HALOGENATED DNA
ABS>In broth, the x-ray sensitivity of the bacteriophage T6 was doubled when 5-bromodeoxyuridine or 5-iododeoxyuridine (BUDR or IUDR) was incorporated. In an aqueous suspension, the immediate and delayed inactivation of phage by x irradiation did not show a significant difference between control, BUDR- incorporated, and IUDR-incorporated phage. This finding supports the view that the phage DNA is a principal target of the direct action of ionizing radiation, whereas the outer coat of the phage is a principal target of the indirect action. X irradiation of aqueous solutions of the critical molecules thymidine, BUDR, and IUDR showed the same degree of optical density decrease with increasing x-ray dose. This indicates that the ring structures of thymidine, BUDR, and IUDR are equally sensitive to radical attack. (auth)
- Research Organization:
- Univ. of Rochester, N.Y.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-18-008175
- OSTI ID:
- 4132430
- Journal Information:
- RAdiation Res., Journal Name: RAdiation Res. Vol. Vol: 21
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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