Dye-Sensitized Photoinactivation of Yeast in Relation to the X-Ray Oxygen Effect

Journal Article · Mon Oct 01 04:00:00 EDT 1962 · Proceedings of the National Academy of Sciences of the United States of America

DOI:https://doi.org/10.1073/pnas.48.10.1738· OSTI ID:4766652

Uretz, R. B.; Haynes, R. H.

Under anaerobic conditions, x rays inflict latent, nonlethal lesions which enhance the sensitivity of surviving cells of yeast to subsequent inactivation by visible light in the presence of the nucleic acid fluorochrome, acridine orange. No such enhanced sensitization occurs if the x rays are delivered under aerobic conditions, or if the order of the radiations is reversed, or when ultraviolet light is substituted for the dye visible light treatment. Thus, conditions which appear to protect cells from the effects of x rays (e.g,, anoxia), may, at the same time, serve to promote the formation of x- ray-induced lesions that sensitize them in other ways.

• Research Organization: Univ. of Chicago
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-001315
• OSTI ID: 4766652
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America, Journal Name: Proceedings of the National Academy of Sciences of the United States of America Journal Issue: 10 Vol. 48; ISSN 0027-8424
• Publisher: National Academy of Sciences, Washington, DC (United States)
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BOILING
DYES
LIGHT
NITRIC ACID
NUCLEIC ACIDS
OXYGEN
PHASE DIAGRAMS
PHOTOCHEMISTRY
RADIATION EFFECTS
RADIATION INJURIES
RADIATION PROTECTION
RADIOSENSITIVITY
TEMPERATURE
THERMODYNAMICS
ULTRAVIOLET RADIATION
URANYL NITRATES
WATER
X RADIATION
YEASTS