THE QUALITY OF ANTIBODY PRODUCED BY TRANSFERRED CELLS

Journal Article · Sat Sep 01 04:00:00 EDT 1962 · Immunology (England)

OSTI ID:4758830

Grey, H M

Comparisons were made of the rate of dissociation of antibody to bovine serum albumin, produced by recipients and donors in cell-transfer experiments, using a saltingout technique. Cells from individual donors were prepared for transfer and injected into either normal adults or adults that had received 400 r whole-body x radiation 24 to 48 hr before transfer. It was found that: antibody formed in most normal and irradiated adult recipients had dissociation rates very similar to those of the donor animals; and antibody formed in most newborn recipients was similar to the antibody formed in the donors with respect to the kinetics of antigen-antibody dissociation. The data support the hypothesis that the recipient animal plays no direct role in the formation of antibody in cell transfer, and that the recipient environment to which the transferred cells are exposed does not appreciably affect the quality of the antibody produced. However, the rate at which gamma -globulin synthesis proceeded was subject to environmental factors involving cellular processes in general. (P.C.H.)

• Research Organization: Scripps Clinic, La Jolla, Calif.
• NSA Number: NSA-17-013898
• OSTI ID: 4758830
• Journal Information: Immunology (England), Journal Name: Immunology (England) Vol. Vol: 5; ISSN IMMUA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
ALBUMINS
ANIMAL CELLS
ANIMALS
ANTIBODIES
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BLOOD SERUM
GLOBULINS
IMMUNITY
PIGMENTS
RADIATION DOSES
TRANSPLANTS
X RADIATION