ANTIBODY PRODUCTION BY IMMUNOLOGICALLY COMPETENT CELLS TRANSFERRED TO A HETEROLOGOUS HOST

Journal Article · Fri Feb 01 04:00:00 EST 1963 · Laboratory Investigation (U.S.)

OSTI ID:4718956

Zlotnick, A

When lymph node cells from rabbits sensitized with bovine serum albumin (BSA) or bovine serum gamma -globulin (BGG) were restimulated in vitro with homologous antigens and transferred to the cheek pouch of x-irradiated (450 r) hamsters, they produced specific antibody in the recipients The antibody produced in the hamsters is identical with rabbit gamma -globulin. Specific changes in the morphology of the transferred cells during the process of antibody production in the heterologous host are described. Changes in the population from small lymphocytes to large mononuclear cells and subsequent differentiation either into plasma cells or into small and medium-sized lymphocytes were noted. Mitotic indexes determined daily after injection of colchicine showed a low mitotic activity on the first 2 days after transfer and increased activity on the third and fourth days after transfer. It is postulated that some of the cells enlarge, divide, and differentiate into cells that contain antiBSA or anti-BGG as a result of the antigenic stimulus with BSA or BGG, and that others enlarge, divide, and differentiate into cells that contain antibody to the host constituents that are foreign to these cells. (TCO)

• Research Organization: Hasassah Univ. Hospital, Jerusalem
• NSA Number: NSA-17-021527
• OSTI ID: 4718956
• Journal Information: Laboratory Investigation (U.S.), Journal Name: Laboratory Investigation (U.S.) Vol. Vol: 12; ISSN LAINA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ALKALOIDS
ANIMALS
ANTIBODIES
BIOLOGY AND MEDICINE
BLOOD SERUM
CHEMICALS
COLCHICINE
DRUGS
HAMSTERS
IMMUNITY
LYMPH SYSTEM
LYMPHOCYTES
MITOSIS
PROTEINS
RABBITS
RADIATION DOSES
X RADIATION