Biochemical Effects of Gamma Irradiation on the Succinoxidase System, in vitro

Journal Article · Fri Jan 01 04:00:00 EST 1960 · Journal of Radiation Research

DOI:https://doi.org/10.1269/jrr.1.120· OSTI ID:4754757

TANAKA, Shozo; GANNO, Shigetake; HATANO, Hiroyuki

The succinoxidase system and each constituent enzyme, (succinic dehydrogenase and cytochrome oxidase), which are obtained from liver of mice and rats and from the heart of the cow, were irradiated in vitro with Co/sup 60/ gamma rays. Inactivation of the enzyme systems was observed to occur with relatively large doses of gamma radiation. Succinic dehydrogenase was found to be more radiosensitive than cytochrome oxidase in all preparations. Effect of gamma irradintion on the enzyme systems localized in mitochondria and on the nuclei of rat liver was compared. The enzyme systems in the nuclear fraction were relatively more radiosensitive to gamma inactivation than those in the mitochondriai fraction. (Abstr. Japan Med., 2: No. 11, Nov. 1962)

• Research Organization: Kyoto Univ.
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-007853
• OSTI ID: 4754757
• Journal Information: Journal of Radiation Research, Journal Name: Journal of Radiation Research Journal Issue: 2 Vol. 1; ISSN 0449-3060
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOCHEMISTRY
BIOLOGY AND MEDICINE
CATTLE
COBALT 60
CYTOCHROME OXIDASE
DEHYDROGENASES
ENZYMES
GAMMA RADIATION
HEART
LIVER
MICE
MITOCHONDRIA
OXIDASES
OXIDATION
RADIATION EFFECTS
RADIOSENSITIVITY
RATS
SUCCINIC ACID