THE MECHANISM OF THE RADIOPROTECTIVE ACTION OF PYRIDOXINE AND OF ITS SULFUR DERIVATIVE 5-ISOTHIURONIUM PYRIDOXINE

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.)

OSTI ID:4753215

Mosin, A F

The effect of pyridoxine and its S-derivative on the level of phospho- lipids and cholesterol in the blood of irradiated animals was investigated considering the concentration changes as an indicator of the injury to the molecular structure of the protoplasma albumin. The survival rate of mice exposed to LD/sub 50/sub 30/ and treated with pyridoxine was found in preliminary tests to be 38% higher than that of the control group; this figure dropped to 30% for the 5-isothiuronium derivative and to less than 20% for 3 other S derivatives. Post-irradiation tests were also carried out on male rabbits exposed to 17 r/min for an integral dose of 1000 r. Results showed that pyridoxine exerts a strong normalizing effect on the phospho-lipids and the cholesterol content of the blood serum while the 5-isothiuronium pyridoxine and mercamine do not exhibit such an effect. (TTT)

• Research Organization: Inst. of Experimental Medicine, Leningrad
• NSA Number: NSA-17-005930
• OSTI ID: 4753215
• Journal Information: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 2; ISSN RADOA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

ALBUMINS
ALKYL RADICALS
AMINES
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BLOOD SERUM
CHOLESTEROL
INDOLES
LIFETIME
LIPIDS
MEA
MERCAMINE
MICE
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
QUANTITY RATIO
RABBITS
RADIATION DOSES
RADIATION PROTECTION
TRYPTAMINES
VITAMIN B-6
VITAMINS