DISTRIBUTION OF INDOL ALKYLAMINES EXHIBITING RADIOPROTECTIVE PROPERTIES IN THE ORGANS OF MICE (in Russian)
The author et al. (Med. Radiobiologiya, 6: 8(1961)) have shown that oxy, methyl, and Cl substitutes in 5 positions of the indol ring of tryptamine yield radioprotective derivatives. In order to determine the importance of the distribution of these materials in the system in causing the radioprotective behavior, the concentration of the derivatives in the various organs of the mice has been determined after peritoneal injection. The following compounds were investigated: 5-methyl tryptamine and 5-methoxy tryptamine which are known to exert radioprotective action; the weakly active 6-methoxy tryptamine, and gamma - 3-indolyl propyl amine and delta -3-indolyl butylamine which are known to be inactive. The preparations were administered at a rate of 90 mg/kg body weight, decapitating animals 15, 30, 60, 120, and 180 minutes later and extracting the amines by a 1% HCl solution. Analysis of the liver, spleen, kidney, lung, brain, muscles, mucous membrane of the intestine, sperm ducts and plasma of the animals showed that the indolamines possessing radioprotective effect were distributed throughout the organism. Previous introduction of the inhibitor monoamine oxydase, alpha -methyl tryntamine changes the distribution oi the 5-methyl tryptamine in the organs. Distribution of these materials in the sensitive organs appears to be responsible for their pharmacological effect and the biochemical reaction. (TTT)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-17-005931
- OSTI ID:
- 4753214
- Journal Information:
- Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 2; ISSN RADOA
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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