INDUCTION BY RADIATION OF LEUKEMIAS AND OTHER MALIGNANT DISEASES OF HEMATOPOIETIC CELLS IN EXPERIMENTAL ANIMALS

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Bulletin of the World Health Organization (U.S.)

OSTI ID:4749944

Mole, R H

A review is presented on mice leukomogenesis. Mice of all strains are generally susceptible to leukemia induction by radiation and nearly all experimental work is carried out on these species. The same kinds of leukemia can also be produced in rats, but the Chinese hamster is strikingly more resistant to leukemogenesis by radiation than the mouse. The classical murine leukemia is thymoma or mediastinal lymphosarcoma. Sufficient irradiation is followed by a high incidence (80 to 100%) of the mediastinal tumor. Single doses of radiation are leukemogenic, although it is rarely possible to raise the leukemia incidence beyond 30%. The frequency of leukemia often increases with dose up to a certain level of dose and then decreases with further increase in dose. In appropriate circumstances almost every, mousw can become leukemic. (P.C.H.)

• Research Organization: Medical Research Council Radiobiological Research Unit, Harwell, Berks, Eng.
• NSA Number: NSA-17-014018
• OSTI ID: 4749944
• Journal Information: Bulletin of the World Health Organization (U.S.), Journal Name: Bulletin of the World Health Organization (U.S.) Vol. Vol: 26; ISSN BWHOA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMALS
BIOLOGY AND MEDICINE
CANCER
CARCINOGENESIS
GENETICS
HAMSTERS
LEUKEMIA
LYMPH SYSTEM
LYMPHOSARCOMAS
MICE
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RATS
THYMUS
TUMORS