Suggested correlation between radiation-induced immunosuppression and radiogenic leukemia in mice
Journal Article
·
· J. Nat. Cancer Inst., v. 51, no. 4, pp. 1211-1215
OSTI ID:4419841
The reduced incidence of reticulum cell sarcoma in RF mice with glomerulosclerosis (GLO) and the demonstration that GLO partly results from an immune response to wild-type virusassociated antigens have provided a means for the determination of the importance of radiation-induced immunosuppression in leukemogenesis. This finding of reduced leukemia risk in mice with GLO has now been extended to include the 2 radiation-induced types, thymic and myeloid. The incidence of radiation-induced leukemia increased with radiation dose in both GLO- positive and GLO-negative mice, but the presence of GLO was associated within each dose group with a twofold reduction in risk for each leukemia. Doses >100 rads suppressed the immune system and the development of GLO and thereby shifted a fraction of the animals from the low-risk (GLO-positive) group to the high-risk (GLOnegative) group. Since GLO is, at least in part in these RF mice, the product of an immune reaction against a virus-associated antigen, suppressing the ability to cope with leukemogenic virusassociated antigens (suppressing the immune system) contributed to the overall leukemogenic effectivness of radiation, at least for doses >100 rads. Since suppression of GLO development did not contribute in the lower dose range (<100 rads) clearly the doseresponse curve for radiation-induced leukemia in the RF mouse cannot be linear. (auth)
- Research Organization:
- Oak Ridge National Lab., TN
- NSA Number:
- NSA-29-000766
- OSTI ID:
- 4419841
- Journal Information:
- J. Nat. Cancer Inst., v. 51, no. 4, pp. 1211-1215, Journal Name: J. Nat. Cancer Inst., v. 51, no. 4, pp. 1211-1215; ISSN JNCIA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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