DIFFERENTIAL RADIOSENSITIVITY OF FIRST- AND SECOND-SET RESPONSES TO ALLOGENIC AND XENOGENIC SKIN GRAFTS IN LETHALLY IRRADIATED MICE

Technical Report · Fri Feb 01 04:00:00 EST 1963

OSTI ID:4749097

Tyan, M L; Cole, L J

Two consecutive BALB/c mouse or rat skin tail grafts were placed on 12 to 14 week old female LAF/sub 1/ mice. One week following the rejection of the second graft, the mice received 870 rad whole-body x radiation and an intravenous infusion of isogemic bone marrow. At various times following irradiation (0.2, 2.0, 13 and 30 days), groups of mice received orthotopic tail skin grafts from LAF/sub 1/, BAJB/c and C3D/2 mice, amd Sprague-Dawley rats. The experimemts were appropriately controlled. The resulting data demomstrated the differential radiosensitivity of firstamd second-set responses to either allogenic (H-2 difference) or xenogenic (rat) skim grafts: i.e., the second-set response of mice pre-sensitized with either allogenic or xenogenic skin grafts is more radioresistant than is the first-set response. The second-set response to a xenogenic skin graft is more radioresistant than is that to an allogenic graft. The converse appears to be true with regard to the first-set response. The theoretical implications of these findings are discussed. (auth)

• Research Organization: Naval Radiological Defense Lab., San Francisco
• NSA Number: NSA-17-015646
• OSTI ID: 4749097
• Report Number(s): USNRDL-TR-619; AD-298632
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
BLOOD VESSELS
BODY
BONE MARROW
IMMUNITY
LETHAL DOSE
MICE
RADIATION DOSES
RADIOSENSITIVITY
RATS
SEX
SKIN
TRANSPLANTS
VARIATIONS
X RADIATION