DIFFERENTIAL EFFECTS OF SPECIFIC ANTISERA ON THE REJECTION OF ALLOGENIC AND XENOGENIC SKIN GRAFTS BY SUBLETHALLY X-IRRADIATED MICE

Technical Report · Fri Mar 01 04:00:00 EST 1963

OSTI ID:4726128

Tyan, M L; Cole, L J

Twelve to fourteen week old female LAF/sub 1/ mice, nonsensitized or pre- sensitized with two consecutive BALB/c or rat skin grafts, received 670 rad whole- body x radiation and orthotopic tail grafts of LAF/sub 1/, BALB/c, C3D/2 and rat skin. Certain groups of mice received specific antisera intraperitoneally, produced in response to BALB/c or rat spleen cells or to two consecutive BALB/c or rat skingrafts. The data indicate that the first-set response to an allogenic skin graft can be significantly inhibited, in sublethally irradiated mice, by speciflc antisera, while the first-set response to a xenogenic skin graft remains resistant to similar treatment. Specific antisera had no effect upon a pre- existing second-set response. The significance of these data is discussed. (auth)

• Research Organization: Naval Radiological Defense Lab., San Francisco
• NSA Number: NSA-17-019810
• OSTI ID: 4726128
• Report Number(s): USNRDL-TR-625; AD-401541
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
ANTIBODIES
ANTISERA
BIOLOGY AND MEDICINE
IMMUNITY
MICE
RADIATION DOSES
RADIATION EFFECTS
SKIN
SPLEEN
TRANSPLANTS
X RADIATION