DIFFERENTIAL RESPONSE TO ALLOGENIC AND XENOGENIC SKIN GRAFTS BY SUBLETHALLY IRRADIATED (670 rad) AND NON-IRRADIATED MICE SENSITIZED BY VARIOUS MEANS

Technical Report · Mon Mar 11 04:00:00 EST 1963

OSTI ID:4694244

Tyan, M L; Cole, L J

Twelve to 14 week old female LAF/sub 1/ mice were presensitized either with 3 i.p. injections of BALB/c or rat spleen or skin cells, or by means of two consecutive BALB/c or rat skin tail grafts. One week following the last injection or the rejection of the second skin graft, the mice either were grafted with LAF/sub 1/, BALB/c, C3D/2 and rat skin or they received 670 rad whole body x radiation and were grafted immediately thereafter. The data indicate that skin grafts induce a more vigorous and more radioresistant second-set response than do dissociated cells. Pre-sensitization with allogenic spleen cells resulted in prolonged survival of subsequent allogenic skin grafts in sublethally irradiated mice. The second-set response to a xenogenic skin graft was found to be more radioresistant than was that to an allogenic graft. The converse was true with regard to the first-set response. (auth)

• Research Organization: Naval Radiological Defense Lab., San Francisco
• NSA Number: NSA-17-021468
• OSTI ID: 4694244
• Report Number(s): USNRDL-TR-628; AD-402294
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
BODY
IMMUNITY
MICE
RADIATION DOSES
RADIOSENSITIVITY
SKIN
SPLEEN
TRANSPLANTS
X RADIATION