INCORPORATION OF S$sup 35$ METHIONINE IN THE BONE MARROW AND SPLEEN PROTEIN IN ACUTE RADIATION SICKNESS AND EFFECTS OF BONE MARROW TRANSPLANTATION ON THE PROCESS

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.)

OSTI ID:4748232

Revis, V A

Protein metabolism in rabbit bone marrow was traced at various stages starting with the moment of exposure to 1100 r and continuing through the recuperating and hematological normalization points. A sharp drop in S/sup 35/- labeled methionine incorporation in the bone marrow, spleen, and skeletal muscle was observed during acute stages. A maximum drop in protein synthesis (0.1 to 0.02% as compared to 4.5, 3.2, and 0.8% in control animals) was observed within 2 weeks of the exposure, The intensity of methionine uptake was restored and even increased to normal (10.6 and 5.5%) two months following the exposure. Therapeutic bone marrow transplantation in rabbits prevents the sharp drop in S/ sup 35/-methionine uptake. (R.V.J.)

• Research Organization: Kalinin Medical Inst., USSR
• NSA Number: NSA-17-015843
• OSTI ID: 4748232
• Journal Information: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 2; ISSN RADOA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

AMINO ACIDS
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BLOOD
BONE MARROW
LABELLED COMPOUNDS
METABOLISM
METHIONINE
MUSCLES
PROTEINS
QUANTITY RATIO
RABBITS
RADIATION DOSES
RADIATION SICKNESS
RECOVERY
SPLEEN
SULFUR 35
TRACER TECHNIQUES
TRANSPLANTS
VARIATIONS