HEMOPOIESIS IN HEALTHY ANIMALS FOLLOWING BONE MARROW TRANSPLANTATION
Journal Article
·
· Probl. Hematol. Blood Transfusion (USSR) (English Transl.)
OSTI ID:4716926
Hematological, histologic, and radioautographic methods were used to study the distribution of homologous bone marrow and effects on hemopoiesis in mice. It was concluded that changes in hematological factors observed during the first 2 days after injection were caused by reaction to the injection and proteins injected with the suspension. Between the 6th and 7th day the transplanted bone marrow cells were actively incorporated into the hemopoietic process. The transplanted cells were rapidly reduced in number. Differential cells continued their development cycle, were converted into mature blood cells, and entered the circulation. The young, undifferentiated transplanted elements seemingly formed foci of extramedullary hemopoiesis. These areas of hemopoiesis were rapidly destroyed by the development of negative immunological reactions. No evidence of primary or secondary immunological complications was observed after the injection of homologous bone marrow cells in healthy animals. (C.H.)
- Research Organization:
- Lenin Inst. of Hematology and Blood Transfusion, Ministry of Health, USSR
- NSA Number:
- NSA-17-023230
- OSTI ID:
- 4716926
- Journal Information:
- Probl. Hematol. Blood Transfusion (USSR) (English Transl.), Journal Name: Probl. Hematol. Blood Transfusion (USSR) (English Transl.) Vol. Vol: 6
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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