THE INFLUENCE OF IRRADIATION ON CHANGES IN THE SERUM ACTIVITY OF LACTIC DEHYDROGENASE IN RATS

Journal Article · Sun Jan 01 04:00:00 EST 1961 · Acta Univ. Carolinae Med., Suppl.

OSTI ID:4738061

Volek, V; Dienstbier, Zd

Changes in serum lactic dehydrogenase (LDH) activity were followed for 4 hr to 4 weeks after whole-body irradiation with 200-kv x rays. The animals were irradiated at a rate of 32 r/min to total doses of 25, 100, 600, and 1000 r. Four hr after irradiation the serum LDH activity fell except with the highest dose, which produced no effect at this time. The 600-r dose diminished activity 35%. After 24 hr the activity was elevated approximates 20% by the 3 highest doses; the effect of all 3 was similar. Thereafter the activity tended to decline and fell below normal by the 3rd postirradiation week. Circulating lymphocytes fell sharply and remained low throughout the period, except after 25 r. When the rats were injected with a solution of LDH immediately after irradiation, the serum LDH activity generally remained elevated for 2 to 3 weeks after irradiation. The changes in activity did not follow a consistent pattern in relation to the radiation dose. (H.H.D.)

• Research Organization: Charles Univ., Prague
• NSA Number: NSA-17-017789
• OSTI ID: 4738061
• Journal Information: Acta Univ. Carolinae Med., Suppl., Journal Name: Acta Univ. Carolinae Med., Suppl. Vol. Vol: 14
• Country of Publication: Country unknown/Code not available
• Language: Czech

Related Subjects

BIOLOGY AND MEDICINE
BLOOD SERUM
DEHYDROGENASES
ENZYMES
LACTIC ACID
LYMPHOCYTES
ORGANIC ACIDS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RATS
X RADIATION