LEUKOPENIA IN DEEP X-RAY THERAPY. CONTRIBUTION TO SOME QUESTIONS OF ITS CONDITIONS OR ORIGIN, ITS THERAPY, AND PROPHYLAXIS

Journal Article · Fri Mar 01 04:00:00 EST 1963 · Strahlentherapie (West Germany)

OSTI ID:4736117

Becker, H; Becker, C

Of the 1776 patients, treated with deep x-ray therapy because of malignant tumors that were examined, 8% were found to be leukopenic. Age, sex, and preceding radiation did not have dispositional influence on occurrence of leukopenia. Low initial vaiues of leukocytes at the start of radiation, irradiation of a large area of the trunk (trunk volume -dose), level of irradiating dose, and temporal dis tribution do have an assured importance. In the first place, occurrence of leukopenia is related to direct radiation damage to the bone-marrow, other causes are radiogenic leukotoxins and an increased destruction of leukocytes by diapedesis. The only effective therapy for radiogenic leukopenia was interruption or scattering of the radiation. ACTH- treatment can increase the leukocytes temporarily. Prophylaxis of leukopenia by vitamin B/sub 12/ was not successful. (auth)

• Research Organization: Martin-Luther -Universitat, Halle- Wittenberg , Ger.
• NSA Number: NSA-17-017941
• OSTI ID: 4736117
• Journal Information: Strahlentherapie (West Germany), Journal Name: Strahlentherapie (West Germany) Vol. Vol: 120; ISSN STRAA
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

ACTH
AGE
BIOLOGY AND MEDICINE
BONE MARROW
CANCER
DRUGS
HORMONES
LEUCOCYTES
MAN
QUANTITY RATIO
RADIATION DOSES
RADIATION INJURIES
RADIOSENSITIVITY
RADIOTHERAPY
RADIOTOXINS
SCATTERING
SEX
VITAMIN B-12
VITAMINS
X RADIATION