THEORETICAL ASPECTS OF CHEMICAL PROTECTION OF MAMMALS AGAINST IONIZING RADIATION

Journal Article · Mon Dec 31 23:00:00 EST 1962 · Zhurnal Obshchei Biologii (U.S.S.R.)

OSTI ID:4733172

Grayevskii, E Ya

The antiradiation action of chemical substances is manifested only if they are present in the organism during irradiation. The protectors differ both with respect to structure and physiological effect. For the most part their protective action is of short duration; for example, cysteine, cysteamine, cystamine, carbon monoxide, sodium nitrite, and paminopropiophenone exert a strong radioprotective effect, and metabolites a moderate degree of protection, for a short time. Conversely, urethane, colchicine derivatives. reserpine, sodium fluoroacetate, and hormones are weak protectors but are active for a prolonged period. The mechanism of the action of chemical protectors has not been fully determined, but two are considered plausible. One is based on anoxia in which radiosensitivity is reduced because of a lowering of the partial pressure of oxygen in the cells. The second is based on alleviation of symptoms of the radiation syndrome by a chemical combination of the protective agents with intracellular structures. (OTS)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-17-019881
• OSTI ID: 4733172
• Journal Information: Zhurnal Obshchei Biologii (U.S.S.R.), Journal Name: Zhurnal Obshchei Biologii (U.S.S.R.) Vol. Vol: 24; ISSN ZOBIA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
ALKALOIDS
AMINES
ANIMALS
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BONES
CARBAMATES
CARBON MONOXIDE
CARCINOGENESIS
CHEMICALS
CYSTAMINE
CYSTEAMINE
CYSTEINE
DOGS
ETHYL RADICALS
HORMONES
MAMMALS
NITRITES
OXYGEN
PLUTONIUM 239
QUANTITY RATIO
RADIATION INJURIES
RADIATION PROTECTION
RADIOSENSITIVITY
RADIUM 226
RADIUM 228
RESERPINE
SODIUM COMPOUNDS
THORIUM 228
TOXICITY
URETHANE