THE PROPHYLAXIS OF RADIATION AFFLICTIONS WITH THE HELP OF COMBINATION OF MEDICINAL AGENTS
The Western and Soviet literature on the use of mixtures of various agents for protection sgainst radiation ailments is reviewed. Good results were obtained with a combination of cysteine and potassium cyanide. It was found that the resistance of animals to radiation sickness increases markedly after acclimatization to hypoxia. The resistance to radiation of such acclimatized mice could be further increased by injecting them before irradiation with cysteamine or cystamine. Cysteine was successfully injected into rats that had received citrine for 30 days previously. These animals proved more resistant to radiation than rats which received only cysteine. Successful use was made of adrenalin and acetyl choline, cysteamine and cystisine, cysteamine and adenosin, triphosphoric acid, cysteine, tryptamine and protamine, sodium nitrite and ethyl alcohol, mixtures of phenatin and its derivatives with mercamine, chlorpromazine with S-aminoethylisothiuronium, aminasine or mepasine with phenatin were used. It was noted that the combined use of adrenocorticotropic hormone and cysteine, far from boosting the prophylactic effect of cysteine, actually led to deterioration of the animals' condition. Other unsuccessful combinations were: cysteamine and strychnine, cysteamine and ginseng, and cysteamine and cholinolytics. It was concluded that effective antiradiation prescriptions can be developed by combining typical sulfhydryl prophylactic agents. (OTS)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-16-014605
- OSTI ID:
- 4785162
- Journal Information:
- Voenno-Med. Zhur., Journal Name: Voenno-Med. Zhur. Vol. Vol: No. 7
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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