Toxicological Studies of Tritiated Thymidine

Journal Article · Mon Apr 01 04:00:00 EST 1963 · Radiation Research

DOI:https://doi.org/10.2307/3571403· OSTI ID:4725954

Samuels, L. D.; Kisieleski, W. E.

Factors influencing the expression of radiotoxicity of tritiated thymidine in the mouse were studied, and parameters for toxicity measurement were evaluated. Uptake and retention of activity were found to be only partially related to total dose given at a single time. Dividing of doses into serial parts increased uptake and retention, whereas increasing the speciflc activity of TdH³ used or increasing the age of the animal decreased uptake and retention. Several parameters for measuring radiotoxicity of TdH³ were studied, but cytological damage to testis was found most consistently and proportionately related to exposure. It is suggested that toxicity of tritiated thymidine is best related to uptake and retention rather than to administered intraperitoneal dose, and that factors influencing uptake and retention may play an important role in expressed radiotoxicity. (auth)

• Research Organization: U.S. Public Health Service, Rockville, Md.; Argonne National Lab., Ill.
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-023067
• OSTI ID: 4725954
• Report Number(s): TID-16928
• Journal Information: Radiation Research, Journal Name: Radiation Research Journal Issue: 4 Vol. 18; ISSN 0033-7587
• Publisher: Radiation Research Society
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
AMINO ACIDS
ANIMALS
BIOLOGY AND MEDICINE
CYTOLOGY
DIET
GONADS
INTESTINE
MEASURED VALUES
MICE
QUANTITY RATIO
RADIATION INJURIES
TESTES
TOXICITY
TRITIUM