TRITIATED THYMIDINE TOXICITY IN MAMALIAN SYSTEMS

Journal Article · Sun Mar 01 04:00:00 EST 1964 · Atompraxis (West Germany) Incorporated in Kerntechnik

OSTI ID:4059873

Samuels, L D; Kisieleski, W E; Baserga, R

Tritiated thymidine has received wide usage during the past five years, with varied concern for its toxicity. Current literature is reviewed for evidences of tritiated thymidine toxicity when administered to mammalian systems. Included are unpublished observations of the authors. Mutagenesis, carcinogenesis, growth inhibition, various cytological anomalies, and cell death were observed following exposure to tritiated thymidine. Problems of calculating radiation dose from tritiated thymidine are mentioned, and the suggestion is made that considerable caution is needed in its use. (auth)

• Research Organization: Public Health Service, Rockville, Md.; Argonne National Lab., Ill.; and Northwestern Univ., Chicago
• NSA Number: NSA-18-017424
• OSTI ID: 4059873
• Journal Information: Atompraxis (West Germany) Incorporated in Kerntechnik, Journal Name: Atompraxis (West Germany) Incorporated in Kerntechnik Vol. Vol: 10; ISSN ATPXA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
ANIMAL CELLS
ANIMALS
BIBLIOGRAPHY
BIOLOGY AND MEDICINE
CARCINOGENESIS
CYTOLOGY
LABELLED COMPOUNDS
LETHAL DOSE
MALFORMATIONS
MEASURED VALUES
MUTATIONS
NUCLEIC ACIDS
ORGANIC NITROGEN COMPOUNDS
QUANTITATIVE ANALYSIS
RADIATION DOSES
RADIATION EFFECTS
RADIOACTIVITY
RADIOSENSITIVITY
SAFETY
SURVIVAL TIME
TESTING
THYMIDINE
TOXICITY
TRITIUM
VARIATIONS