CHANGES OF ARTERIAL BLOOD PRESSURE IN ACUTE RADIATION DISEASE
Journal Article
·
· Arch. Intern. Pharmacodyn.
OSTI ID:4725714
Acute experiments were done in cats and chronic experiments in dogs. The cats were subjected to whole-body x irradiation with a dose of 1500 r, and were examined on the third day after irradiation, when radiation disease was fully developed. Reflexes from the baro- and chemoreceptors were investigated, and arterial blood pressure was recorded in the irradiated cats after intravenous administration of adrenaline, noradrenaline, serotonin, acetylcholine, histamine, Regitine, atropine, or Pendiomid. Dogs were subjected to whole-body irradiation with 800 r,; changes in arterial blood pressure, which occurred after the administration of neurohormones, were investigated before and after irradiation. Pressor reflexes in irradiated cats, elicited by clamping and unclamping of both common carotid arteries, corresponded to a rise from 129.6 to 141.4 mm Hg, as compared to pressor reflexes in nonirradiated cats from 106.6 to 146. Reflexes from carotid sinus chemoreceptors evoked by 0.5% KCl were also weaker in irradiated cats. The results of both the acute and chronic experiments indicate that circulatory changes occur in radiation disease. The changes mainly involve responses of the circulatory system to neurohormones and stimulation of vascular baro- and chemoreceptors. (TCO)
- Research Organization:
- Medical Academy, Warsaw
- NSA Number:
- NSA-17-023216
- OSTI ID:
- 4725714
- Journal Information:
- Arch. Intern. Pharmacodyn., Journal Name: Arch. Intern. Pharmacodyn. Vol. Vol: 140
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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