THE BEHAVIOUR OF VASCILAR REACTIONS IN ACUTE IRRADIATION DISEASE

Journal Article · Fri Jan 01 04:00:00 EST 1960 · Acta Phys. Polon.

OSTI ID:4105738

Ryzewski, J

Acute experiments were made with cats, and chronic experiments with dogs. The a cute experiments numbered 377 and concerned 65 rats of either sex and different weights in urethan anesthesia. Another 22 cats were used for 65 control experiments. The cats received a total dose of 1500 r from a therapeutic x-ray unit. The conditions were: distance, 60 cm; O.5 mm copper filter; 160 kv; 20 ma; 29 r/min. The cats were examined on the third day after irradiation, when the irradiation disease picture was developed. Vascular reflexes from the interoceptors of the carotid sinus were investigated after Heymans's method, reflexes from the interoceptors of spleen and intestinal loop vessels after Czernigowski's method, and reflexes from interoceptors of hind-leg vessels after the author's method. Adrenaline, noradrenaline, serotonin, acetylcho-line, potassium chloride, and lactic acid were used to stimulate interoceptors. To stimulate the proximal section of the sciatic nerve and peripheral part of the splanchnic nerve, electric current was used --3 to 6 volts, 20 ma, 20 sec. Furthermore, arterial blood pressure was measured in irradiated cats after intravenous administration of adrenaline, noradrenaline, serotonin, acetylcholine, or histamine. Experiments were also made with cats poisoned with phentolamine, atropine, or pendiomid. The experimental material was analyzed statistically. Chronic experiments numbered 165 and concerned 6 dogs. Before irradiation, the dogs were opperated upon after the author's method to enable blood pressure to be measured by intravascular technique, and subsequently standards of arterial blood pressure reaction to adrenaline, noradrenaline, serotonin, acetylcholine, and histamine were determin+d. In the experiments, the dogs received a total dose of 800 r from a therapeutic x ray unit. Conditions were: distance, 80 cm; O.5 mm Cu filter; l60 Kv; 20 ma; 21 r/min. Alrterial blood pressure reaction to the above neurohormones was investigated in the irradiated dogs daily. Experiments with dogs poisoned with phentolamine or pendiomid were also carried out. The experiments referred to showed ionizing radiation to reduce considerably reflexes from vascular chemoreceptors to neurohormones, potassium chloride, and lactic acid. In irradiated cats, pressor reflexes from carotid sinus mechanoreceptors were diminished, and so were pressor reflexes to electric stimulation of the sciatic and splanchnic nerves. Neurohormones, such as adrenaline and noradrenaline, caused in cats and dogs lower-than-standard effects. Depressor effects of serotonin were in irradiated and noniirradiated cats equal in strength. In dogs, on the other hand, pressor effects of serotonin diminished in strength with the progress of irradiation disease. Pressure fall evoked by aby acetylcholine and histamine was the same in irradiated and nonirradiated cats and dogs, but of considerably longer duration in irradiated animals. Phentolamine diminished pressor effects of adrenaline in irradiated cats and dogs, and also weakened in dogs the pressor effects of serotonin. Atropine and phentolamine increased in irradiated cats and dogs pressor effects of adrenaline and noradrenaline, and pressor effects of serotonin in dogs. It was concluded that in acute irradiation disease the adrenergic part of the autonomic nervous system, first of all sensory and vasomotor terminals, is injured. Also, preserved vasomotor reflexes, even though weakened, enable in this disease an influence to be exerted on the functional efficiency of the circulatory system. (auth)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-15-008582
• OSTI ID: 4105738
• Journal Information: Acta Phys. Polon., Journal Name: Acta Phys. Polon. Vol. Vol: 11
• Country of Publication: Country unknown/Code not available
• Language: Polish

Related Subjects

ANESTHESIA
ANIMALS
BIOLOGY AND MEDICINE
BLOOD VESSELS
CATS
DOGS
GLANDS
HORMONES
INTESTINE
NERVOUS SYSTEM
POTASSIUM CHLORIDES
RADIATION SICKNESS
SPLEEN
STATISTICS
X RADIATION