EFFECT OF LARGE DOSES OF HEAD IRRADIATION IN DOGS

Journal Article · Fri Aug 01 04:00:00 EDT 1958 · American Journal of Physiology (U.S.)

OSTI ID:4321032

Peng, M; Chien, S; Gregersen, M I

Dogs in which the head was x-irradiated with 23,500 r survived from 14 to 25 hours. The chief neurological signs were disturbance of equilibrium and extensor rigidity. Throughout the whole postirradiation course, the blood volume showed very little change. Arterial pressure. heart rate and respiratory rate remained essentially unchanged until about 1 hour before death. The carotid sinus reflex did not change until 30 to 60 minutes before death, but then deteriorated rapidly. Generally, the respiratory response to cyanide injection was still present after the disappearance of the carotid sinus reflex. At the terminnl stage, the pressor response of the medullary vasomotor center to electrical stimulation decreased in parallel to that of the carotid sinus reflex. The vital centers in the medulla oblongata are directly damaged by large doses of xirradiation. The failure of respiration is the cause of death. (auth)

• Research Organization: Columbia Univ., New York
• NSA Number: NSA-12-016094
• OSTI ID: 4321032
• Journal Information: American Journal of Physiology (U.S.), Journal Name: American Journal of Physiology (U.S.) Vol. Vol: 194; ISSN AJPHA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD
BLOOD VESSELS
BRAIN
CAROTID SINUS
CYANIDES
DOGS
ELECTRODES
EQUILIBRIUM
HEAD
HEART
LUNGS
MEDICINE
MUSCLES
NERVOUS SYSTEM
PHYSIOLOGY
PRESSURE
RADIATION DOSES
RADIATION INJURIES
REFLEXES
SURVIVAL TIME
VARIATIONS
X RADIATION