THE TOXICITY OF PROCAINE IN THE RADIATIO-INJURED MOUSE

Journal Article · Mon May 01 00:00:00 EDT 1961 · Arzneimittel-Forsch.

OSTI ID:4725686

Winne, D

Experiments were carried out in mice to determine whether procaine shows altered pharmacologic activity in irradiated animals. The mice were x irradiated with 700 r. (LD/sub 99.5/30/) and the convulsive action of procaine was tested 7 days later by intraperitoneal injection of 38 to 91 g of the drug per gram body weight. The mean convulsive dose for unirradiated animals was 44 g/g and the same dose was found in irradiated mice. The respective procaine LD/sub 50/ values were 74 and 72 g/g. Body weight of the irradiated mice fell 15% in the 7-day period. The results indicate that the sensitivity of the mouse to procaine is not affected by the radiation syndrome. (H.H.D.)

• Research Organization: Max-Planck-Gesellschaft, Goettingen, Ger.
• NSA Number: NSA-17-023217
• OSTI ID: 4725686
• Journal Information: Arzneimittel-Forsch., Journal Name: Arzneimittel-Forsch. Vol. Vol: 11
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BODY
DRUGS
LETHAL DOSE
MICE
NERVOUS SYSTEM
PROCAINE
QUANTITATIVE ANALYSIS
QUANTITY RATIO
RADIATION DOSES
RADIATION INJURIES
RADIOSENSITIVITY
TESTING
TOXICITY
VARIATIONS
WEIGHT
X RADIATION