Radiation-induced abnormality and growth disturbance in the mouse fetus

Journal Article · Thu Mar 01 04:00:00 EST 1973 · Igaku No Ayumi, v. 84, no. 13, pp. 760-770

OSTI ID:4394681

Ueda, K; Yoshizawa, Y

Six hundred and forty pregnant mice of ddY strain with the mean frequency distribution of 9.41 plus or minus 2.30 litter size and 6.020 of their fetuses were examined in the experiment. Pregnant mice with fetuses at the gestation age between 7 to 13 days old were irradiated with 200 R (3.3 R/min) of gamma radiation at 2 pm, 7 pm, and 12 am respectively except those with 11-day- old fetuses who received 200 R of irradiation at 4 am, 9 am, 2 pm, and 12 am. In order to obtain correlation between the rate of abnormality in the limbs and radiation dose, 11-day-old fetuses were irradiated with 75, 100, 150, 200, 250, and 300 R for 1 hr. respectively. All of these irradiated groups of fetuses were taken from the maternal body and observed by microscopy. Abnormality appeared first in the forelimbs of the 11-day-old fetuses followed by abnormality found in the hindlimbs. Bradyphalangia was observed in 50% of the 11-day-old fetuses, while congenital anomalies of the hand and fingers were observed in the 9 am, 2 pm, and 7 pm irradiated groups. The rate of abnormality and body weight showed radiation dose dependency. One hundred percent abnormality was observed in the fetuses with 250 R of irradiation. Changcs in fetus body weight was in inverse proportion to thc rate of abnormality. Ossification of the caudal vertebrae started around 17 days old since gestation in the 11-day-old irradiated fetuses in which correlation between ossification and body weight was recognized. In the groups received with 50 mu g and 100 mu g of Cd intraperitoneally combined with irradiation, maternal death and abortion or premature delivery were observed. Even in the surviving animals, the death rate of fetuses increased. When saline solution was administered intraperitoneally to the pregnant mice with 200 R of irradiation, the rate of abnormality increased and further increased with Cd administration. (JA)

• Research Organization: Tokyo Univ.
• NSA Number: NSA-29-000728
• OSTI ID: 4394681
• Journal Information: Igaku No Ayumi, v. 84, no. 13, pp. 760-770, Journal Name: Igaku No Ayumi, v. 84, no. 13, pp. 760-770; ISSN IGAYA
• Country of Publication: Japan
• Language: Japanese

Related Subjects

*CADMIUM-- RADIOSENSITIVITY EFFECTS
*FETUSES-- BIOLOGICAL RADIATION EFFECTS
*LIMBS-- MALFORMATIONS
DOSE-RESPONSE RELATIONSHIPS
GAMMA RADIATION
GROWTH
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
PHOTON BEAMS
PRENATAL IRRADIATION
SURVIVAL CURVES
VERTEBRAE
WEIGHT