A SPECIFIC IMMUNOLOGICAL TOLERANCE IN RADIATION CHIMERAS

Journal Article · Mon Oct 01 04:00:00 EDT 1962 · Transplant. Bull.

DOI:https://doi.org/10.1097/00006534-196210000-00043· OSTI ID:4724872

Vos, O; Weyzen, W W.H.

Repopulation of the bone marrow and lymph nodes with donor-type cells was demonstrated in C57BL/Rij and (CBA/Rij x C57BL/Rij)F/sub 1/ mice that had been exposed to a lethal dose of total body x irradiation and treated with CBA bone marrow cells. No apparent symptom s of secondary disease were found in those chimeras that survived 100 days after irradiation and bone marrow transplantation. The same sensitivity to a graft-vs-host reaction was found in C57BL and F/sub 1/ mice and long-term CBA yields C57BL and CBA YY F/sub 1/ chiumeras, as tested by the killing effect of CBA lymph node cells. Therefore, no alteration in sensitivity to a graft-vs-host reaction occurred in long-term chimeras. CBA lymph node cells derived from long-term chimeras showed the same immunologcal activity against isoantigens of a third (RF) strain as CBA lymph node cells from normal CBA mice, but no killing effect of chimeric lymph node cells could be demonstrated in irradiated C57BL or (CBA X cal tolerance of the donortype lymphoid cells towards the host's isoantigens occurred in the long-term chimeras studied. (auth)

• Research Organization: National Defense Research Organization T.N.O., Rijswijk, Netherlands
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-010474
• OSTI ID: 4724872
• Journal Information: Transplant. Bull., Journal Name: Transplant. Bull. Vol. Vol: 30
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
ANTIGENS
BIOLOGY AND MEDICINE
BODY
BONE MARROW
IMMUNITY
LETHAL DOSE
LYMPH NODES
LYMPH SYSTEM
MICE
SENSITIVITY
X RADIATION