“KILLING EFFECT” OF INJECTED LYMPH NODE CELLS IN HOMOLOGOUS RADIATION CHIMERAS

Journal Article · Mon Oct 01 04:00:00 EDT 1962 · Plastic and Reconstructive Surgery

DOI:https://doi.org/10.1097/00006534-196210000-00042· OSTI ID:4720763

Vos, O.; Weyzen, W. W. H.

The repopulation of lymph nodes and the killing effect of CBA/Rij lymph node cells injected at various times after irradiation were investigated in lethally irradiated C57BL/ Rij and (CBA/Rij x C57BL/Rij) F/sub 1/ mice treated with CBA bone marrow. A correlation was found between the degree of atrophy of the lymph nodes and the number of cells needed to kill the host. During the first days after irradiation, a hlgh degree of atrophy and a small ED/sub 50/ for lymph node cells (50,000 to 200,000) were observed. The repopulation of the lymph nodes increased in parallel with the number of lymph node cells that had to be injected to give a killing effect. This process occurred more rapidly in F/ sub 1/ than in C57BL mice. A competitive repopulation of tolerant lymph node cells originating from the transplanted bone marrow cells and the injected immunologically active lymph node cells was postulated to explain this observation. (auth)

• Research Organization: National Defense Research Organization T.N.O., Rijswijk, Netherlands
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-010473
• OSTI ID: 4720763
• Journal Information: Plastic and Reconstructive Surgery, Journal Name: Plastic and Reconstructive Surgery Journal Issue: 4 Vol. 30; ISSN 0032-1052
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
BONE MARROW
IMMUNITY
IRRADIATION
LETHAL DOSE
LYMPH NODES
LYMPH SYSTEM
MICE
TRANSPLANTS