Fate of Tritiated Native Liver Deoxyribonucleic Acid Injected into Lethally Irradiated Rats

Journal Article · Sat Apr 13 04:00:00 EST 1963 · Nature

DOI:https://doi.org/10.1038/198165a0· OSTI ID:4718955

Popovic, A; Becarevic, A; Kanazir, D; Stosic, N; Pantic, V

The fate of native homologous liver tritiated desoxyribonucleic acid (DNA) was followed by means of radioautographic techniques after injection into lethally irradiated rats. Results indicate the incorporation of the tritiated DNA into the nuclei of some cells of the testes, intestines, spleen, and liver of irradiated recipients. The macrophages appeared to be involved in the transport of injected DNA. Metabolism of the liver nucleic acid ot irradiated DNAtreated animals appeared to return almost to normal. (C.H.)

• Research Organization: Inst. of Nuclear Sciences "Boris Kidrich," Belgrad
• NSA Number: NSA-17-021530
• OSTI ID: 4718955
• Journal Information: Nature, Journal Name: Nature Vol. Vol: 198
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOCHEMISTRY
BIOLOGY AND MEDICINE
GONADS
INTESTINE
IRRADIATION
LETHAL DOSE
LIVER
NUCLEIC ACIDS
RADIOAUTOGRAPHY
RATS
SPLEEN
TRACER TECHNIQUES
TRITIUM