EXPERIENCE WITH INTRACAVITARY TREATMENT WITH COLLOIDAL RADIOGOLD

Journal Article · Sun Jan 01 04:00:00 EST 1961 · Neoplasma (Czechoslovakia)

OSTI ID:4718490

Hupka, S; Simko, S; Siracky, J; Skupenova, A

The technique of intraperitoneal injection of Au/sup 198/ is described and a lead-shielded apparatus for carrying out the infusion, and which protects the operator from radiation, is illustrated. Dose distribution is also considered from a theoretical viewpoint and exainined by scintillometry. The relation of the dosy (D) delivered to the peritoneum to the thickness of the fluid layer containing Au/sup 198/ was expressed as: D = 3.75 x 10/sup 4/ x S/V x F, where S is the amount of Au/sup 198/ injected in mC, V the volume of injected solution, and F a factor determined by the thickness of the layer. D reaches a maximum at a thickness of approximates 4 mm, and would be approximates -7100 r after injection of 100 ml containing 100 mC. It was estimated that gamma radiation would account for 10% of the BETA dose. In the treatment of cancer patients to diminish ascites, 100 to 150 mC of Au/sup 198/ injected in 40 to 75 ml resulted in leukopenia, anorexia, and vomiting but an 80 mC dose did not influence blood cells or produce subjective symptoms. (P.C.H.)

• Research Organization: Oncological Research Inst., Bratislava
• NSA Number: NSA-17-017682
• OSTI ID: 4718490
• Journal Information: Neoplasma (Czechoslovakia), Journal Name: Neoplasma (Czechoslovakia) Vol. Vol: 8; ISSN NEOLA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BETA PARTICLES
BIOLOGY AND MEDICINE
BLOOD CELLS
CANCER
COLLOIDS
DISTRIBUTION
EQUATIONS
GAMMA RADIATION
GOLD 198
LEAD
LEUCOCYTES
MAN
PERSONNEL
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIOTHERAPY
SCINTILLATION COUNTERS
SHIELDING
SOLUTIONS