CLINICAL RESULTS WITH CORTISONE ACTION IN THE GENERALIZED RADIATION SYNDROME, WITH SPECIAL CONSIDERATION OF DELTA-1-DEHYDROHYDROCORTISONE

Journal Article · Sun Jan 01 04:00:00 EST 1961 · Chemotherapia (Switzerland) Changed to Chemotherapy (Basel)

DOI:https://doi.org/10.1159/000219544· OSTI ID:4729212

Freyer, B

The effects of adrenal steroid therapy were studied in 43 patients undergoing x-ray, Ra, and Au/sup 198/ treatments for malignant tumors. The postirrathation symptom s included anorexia, nausea, vomiting, other gastrointestinal disorders, and headache. In one group of patients who received up to 6000-r x-ray or 40 to 300 mC Au/siSTA 198/ doses, subsequent treatment with prednisolone at 5 mg/day completely prevented the symptoms. It was also effective when given in doses of 10 to 20 mg/day before irradiation in another group of patients. Prednisolone tended to prevent the rise in circulating eosinophils due to irradiation, and although it tended to aggravate the lymphopenic reaction after irradiation, it did not appear to produce undesirable sideeffects. Combined treatment of a third group of irradiated patients with 10 mg prednisolone + 40 units thyroxine daily appeared to prevent serum electrolyte (K and Na) and blood sugar changes resulting from irradiation. The steroid also had a euphoric effect and reduced the pain of irradiated patients. (H.H.D.)

• Research Organization: Rontgen- und Strahleninstitut, Staditisches Rudolph Virchow Krankenhaus, Berlin
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-010268
• OSTI ID: 4729212
• Journal Information: Chemotherapia (Switzerland) Changed to Chemotherapy (Basel), Journal Name: Chemotherapia (Switzerland) Changed to Chemotherapy (Basel) Vol. Vol: 3; ISSN CMTRA
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

BIOLOGY AND MEDICINE
CANCER
CORTISONE
GOLD 198
HORMONES
LYMPHOCYTES
MAN
MEDICINE
PREDNISONE
QUANTITY RATIO
RADIATION DOSES
RADIATION SICKNESS
RADIOTHERAPY
RADIUM
STEROIDS
THYROXINE
X RADIATION