ON THE THERAPY OF MALIGNANT THYROID TUMORS

Journal Article · Fri May 10 04:00:00 EDT 1963 · Aerztliche Forschung (West Germany) Discontinued

OSTI ID:4717744

Strohm, C; Czempiel, H

The relative advantages of various radiation treatments (200-kv x rays, Co/sup 60/ gamma rays, high-speed electrons, radioiodine) are discussed and results of thyroid dosimetric neck structures were used to measure thyroid doses under various types of radiation. Isodose diagrams obtained with a water-filled Plexiglas phantom showed that 6000-r, ventrally directed, combined Co/sup 60/ and 17-Mev electron irradiation would be most effective delivering 60 to 90% of the surface dose to the gland. Under these conditions, vertebral bone marrow would receive only 10 to 20% of the superficial dose. I/sup 131/ treatment of thyroid tumors has the disadvantage of low incorporation in some types of tumors and the advantage that it is taken up by metastases as well as the primary tumor. In general, 100- to 150-mC oral doses of I/sup 131/ initially are recommended, to be followed 14 days later by a similar dose. The highest total dose given was 680 mC. Of patients given a single 120-mC dose of I/sup 131/, 44% showed a fall of circulating lymphocytes to a level 52% of the initiai value. Two weeks after a 240-mC dose, the level fell sharply, and in 6 to 8 weeks myxedema was noted. Total circulating leukocytes fell to approximates 30% of normal by 1 month after a 120-mC dose. Of 62 patients with thyroid tumors treated with I/sup 131/ and 200-kv x rays, only 18% were living after 1 yr. (H.H.D.)

• Research Organization: Universitat, Munich
• NSA Number: NSA-17-026966
• OSTI ID: 4717744
• Journal Information: Aerztliche Forschung (West Germany) Discontinued, Journal Name: Aerztliche Forschung (West Germany) Discontinued Vol. Vol: 17; ISSN ARZFA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
CANCER
COBALT 60
ELECTRONS
GAMMA RADIATION
IODINE 131
LEUCOCYTES
MAN
MEASURED VALUES
METASTASES
MOCKUP
PHANTOMS
QUANTITY RATIO
RADIATION DOSES
RADIOTHERAPY
THYROID
X RADIATION