Modification of Irradiation Effects Through Actively Acquired Tolerance to Homologous Bone Marrow Grafts
Journal Article
·
· Experimental Biology and Medicine
Host and donor pigeons made immunologically tolerant in various combinations by skin grafting shortly after hatching were exposed to lethal doses of irradiation at the age of 8 to 10 months. Homologous bone marrow transplants showed that the tolerant state of the host did not appreciably affect survival and tolerance of marrow donors for host increased mean survival by about 10 days. These data suggest that the immunologic mechanism of the donor s more important than that of the host in producing homologous disease in the pigeon.
- Research Organization:
- Univ. of Wisconsin, Madison
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-023135
- OSTI ID:
- 4717087
- Journal Information:
- Experimental Biology and Medicine, Journal Name: Experimental Biology and Medicine Journal Issue: 1 Vol. 112; ISSN 1535-3702
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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