Influence of Sex on Bone Marrow Transplantation in Mice With Induced Tolerance

Journal Article · Fri Dec 01 04:00:00 EST 1961 · Experimental Biology and Medicine

DOI:https://doi.org/10.3181/00379727-108-27036· OSTI ID:4794641

Cristoffanini, A. P.; Long, E. V.; Tocantins, L. M.

Mice of A/Jax and C₃H strains were injected at birth with bone marrow cells from females of the opposite strain in an attempt to induce tolerance. Skin grafting experiments demonstrated that both males and females so treated did acquire a slight degree of tolerance. When the partially tolerant female mice were used as donors or hosts in homologous bone marrow transplantation experiments (with the opposite strain), the date of appearance of the secondary disease was delayed, an effect attributable to acquired tolerance. However, when partially tolerant males were used, survival did not increase, but actually decreased. The animals died in a very short time, as if hypersensitized. It has been proposed that the tolerant animals are chimeras; if so, the male animals may contain female cell already hypersensitized against male, and these hyperseisitized cells may be responsible for the short survival.

• Research Organization: Jefferson Medical Coll., Philadelphia
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-009773
• OSTI ID: 4794641
• Journal Information: Experimental Biology and Medicine, Journal Name: Experimental Biology and Medicine Journal Issue: 3 Vol. 108; ISSN 1535-3702
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
BONE MARROW
GRAFTS
IMMUNITY
LIFETIME
MICE
SEX
SKIN
TRANSPLANTS