GRAFTED-MARROW-REJECTION MORTALITY CONTRASTED TO HOMOLOGOUS DISEASE IN IRRADIATED MICE RECEIVING HOMOLOGOUS BONE MARROW

Journal Article · Sun Feb 01 04:00:00 EST 1959 · Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst.

OSTI ID:4272757

Trentin, J J

ABS>Bone marrow from the BALB/c and CBA inbred strains of mice and the (BALB/c x CBA)F/sub 1/ hybrid strain was injected isologously and in various homologous combinations into CBA and (BALB/c x CBA)F/sub 1/ hybrid mice irradiated with 330 r, 550 r, or 770/r. At the sublethal dose of 330 r, no mortality resulted from any combination of marrow donor and recipient. At the higher doses, two types of mortality were observed in mice receiving bone marrow. Early mortality resulted 5 to 21 days after the ordinarily high sublethal dose of 550 r and delayed mortality resulted 21 to 60 days following good, early protection against the otherwise lethal dose of 770 r. Neither type of mortality occurred after administration of isologous marrow, but both types occurred after administration of marrow from an unrelated homologous strain. When F/sub 1/ marrow was transferred into the parental strain only early mortality was observed. When parental marrow was transferred into the F/sub 1/ hybrid only delayed mortality was observed. From these observations and other considerations it is concluded that the early mortality, resulting from administration of homologous or heterologous marrow into mice irradiated in the high sublethal or midlethal dose range, is the result of the recovered ability of the host to reject the temporarily grafted marrow, whereas the delayed mortality, following good, early protection against otherwise lethal doses of irradiation with homologous or heterologous marrow, usually results from an immunologic reaction of the grafted marrow derivatives against the tolerant host. The former type of mortality was designated grafted-marrow-rejection mortality; the latter, homologous disease or heterologous disease. (auth)

• Research Organization: Baylor Univ. Coll. of Medicine; and Univ. of Texas Dental Branch, Houston, TExas
• NSA Number: NSA-13-008576
• OSTI ID: 4272757
• Journal Information: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst., Journal Name: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst. Vol. Vol: 22; ISSN JNCIA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BONE MARROW
GENETICS
IMMUNITY
LETHAL DOSE
MICE
RADIATION INJURIES
RADIATION PROTECTION
SURVIVAL TIME
TRANSPLANTS
X RADIATION