TRANSPLANTATION OF HOMOLOGOUS AND HETEROLOGOUS LYMPHOID CELLS IN X- IRRADIATED AND NON-IRRADIATED MICES

Journal Article · Wed Jul 01 04:00:00 EDT 1959 · Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst.

OSTI ID:4223526

Vos, O; DeVries, M J; Collenteur, J C; Van Bekkum, D W

The injection of a large number of homologous lymphoid cells kills x- irradiated mice protected with isologous or homologous bone marrow within 1 to 2 weeks. The injection of a smaller number of homologous lymphoid cells kills the mice after a longer interval. Parental-strain lymphoid cells have a detrimental effect in irradiated F/sub 1/ hybrids, but F/sub 1/ hybrid lymph-node cells produce no ill effect in parental-strain mice. Rat lymph-node cells only have a lethal effect in irradiated mice protected with heterologous bone marrow when the cells are injected at 24 hours after irradiation. On the basis of the number of cells required to produce a certain percentage of mortality, homologous lymph- node cells are somewhat more effective than homologous spleen cells, but much more eftective than homologous thymus cells. Mice that died 10 to 20 days or later after injection of homologous or heterologous lymphoid cells had symptoms and lesions which resembled those seen in mice that died from the secondary disease after foreign bone marrow transplantation. A pathological syndrome resembling the secondary disease has been evoked in a certain number of nonirradiated F/sub 1/ hybrid mice by the injection of a large number of lymphoid cells from parental strain mice that had been sensitized against isoantigens of the other parental strain. These observations support the concept of a graft- antihost reaction that is involved in the development of secondary disease. (auth)

• Research Organization: National Defense Research Council TNO, Ryswick, Netherlands
• NSA Number: NSA-13-017706
• OSTI ID: 4223526
• Journal Information: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst., Journal Name: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst. Vol. Vol: 23; ISSN JNCIA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANTIGENS
BIOLOGY AND MEDICINE
BONE MARROW
CYTOLOGY
DISEASES
EFFICIENCY
IMMUNITY
LYMPH SYSTEM
LYMPHOCYTES
QUANTITY RATIO
RADIATION PROTECTION
RATS
SURVIVAL TIME
THYMUS
TRANSPLANTS
VARIATIONS
X RADIATION