ON THOROTRAST INJURY WITH DEVELOPMENT OF A HEMANGIOENDOTHELIAL SARCOMA OF LIVER
A review is presented on the tumorogenic action of thorotrast and a new case is presented. A male patient had been subjected in 1933 to a dozen or so thorotrast injections over a 2-week period in examinations for a kidney stone. In 1948 he developed cirrhosis, with clinical evidence of extensive ThO/sub 2/ deposits, and died 6 yr later of gastrointestinal bleeding. Antemortem radiographs of the liver showed marked opacity owing to accumulation of the contrast medium, and postmortem radioautographs of liver, spleen, and lymph nodes showed considerable radioactivity in reticuloendothelial Sells. Liver parenchyma was largely replaced by fibrous tissue containing massive ThO/sub 2/ deposits, which showed a tendency toward calcification. Kupffer cells of the liver were also filled with ThO/sub 2/. A metastasizing cavernous hemangioma was present in the liver. The spleen, which was markedly enlarged and lacking follicles, showed higher levels of radioactivity than the liver. ThO/sub 2/ was also present in bone marrow, where fatty and fibrous replacement, with concomitant depression of erythropoiesis, were evident. The observed premalignant adenomatous hyperplasia of liver as well as the malignant hemangioma were attributed to thorotrast deposition in the liver. (H.H.D.)
- Research Organization:
- Krankenhaus Furth i. B. Munich
- NSA Number:
- NSA-17-027190
- OSTI ID:
- 4715178
- Journal Information:
- Zeitschrift fuer Krebsforschung (West Germany) Superseded by Z. Krefsforsch. Klin. Onkol., Journal Name: Zeitschrift fuer Krebsforschung (West Germany) Superseded by Z. Krefsforsch. Klin. Onkol. Vol. Vol: 64; ISSN ZEKBA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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