HODGKIN'S DISEASE FOLLOWING ADMINISTRATION OF THOROTRAST
A case of Hodgkin's disease developing 12 yr following administration of ThO/sub 2/ is reported, representing the only known example of this disease associated with Th. Radiography of the abdomen showed increased density of the liver and spleen, as well as radiopaque densities in the abdomen presumably representing nodes which were heavily infiltrated with ThO/sub 2/. The densities in the liver and spleen were also ascribable to ThO/sub 2/ deposits. The tumor consisted of pleomorphic round and polyhedral cells and Reed-Sternberg cells, along with areas of fibrosis, necrosis, hemorrhage, and mononuclear cell reaction. Pleomorphic cellular changes were frequentiy found adjacent to deposits of ThO/ sub 2/. ThO/sub 2/ was also found throughout the reticuloendothelial system, as in the reticulum cells of the liver, spleen, and lymph nodes. Using a gas-flow counter, significant counts of radiation were detected in the spleen and periaortic lymphoid tissues, sites histologically demonstrated to contain Th and tumor Proliferated bile ducts in hepatic portal areas were of interest because of reported bile duct carcinoma of the liver in patients previously receiving Thorotrast. The presence of tumor cells in the reticuloendothelial system surrounding granules of ThO/sub 2/ suggests that Th induced or inttiated the development of Hodgkin's disease with spread to the kidneys and other organs containirg little or no Th. A table is given listing anatomic sites where tumors associated with Thorotrast have been found in the commonly recognized types of tumors in rough order of incidence. It is suggested that there is ample evidence to incriminate Thorotrast as a definite oncogenic agent. (H.H.D.)
- Research Organization:
- Duke Univ., Durham, N.C.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-033750
- OSTI ID:
- 4671146
- Journal Information:
- Southern Med. J., Journal Name: Southern Med. J. Vol. Vol: 56
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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