ADDENDUM: MECHANISMS OF LIPID PEROXIDE FORMATION IN RAT TISSUE HOMOGENATES
Results are reported from studies of factors involved in the production of peroxides in certain tissues, such as brain and liver, and factors in those tissues that do not produce peroxides that make them different from the peroxide- forming group. It was concluded that a complex of inhibitors is available in tissues, and that these inhibitors normally are present in the whole tissue homogenate, as well as in the whole intact tissue. However, it appears that homogenization and dilution break down a certain number of these. These inhibitors might include such things as the breakdown of the normal iron binding in tissues. In some tissues a sufficient amount of this antioxidant complex is broken down to allow for peroxidation to occur in aerobically incubated homogenates. Such tissues include the brain, liver, and kidney. In certain other tissues, a reserve of antioxidant material presumably is left, such as that in the protein fraction, which will inhibit peroxidation. This appears to be the case for testis and intestinal mucosa. (auth)
- Research Organization:
- Univ. of California, Los Angeles
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-024976
- OSTI ID:
- 4704663
- Journal Information:
- Radiation Res., Suppl. 3, Journal Name: Radiation Res., Suppl. 3
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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