THE EFFECT OF X-IRRADIATION ON THE ANTIOXIDANT ACTIVITY OF MAMMALIAN TISSUES
Tissue antioxidant activity was measured by the capacity of tissue supernatants to inhibit peroxide formation whem added to rat liver homogenate. Blood, ascitic fluid, imtestinal mucosa, amd bone marrow had the highest antioxidant activity. Testis amd spleen had less, and liver and brain had none. Peroxide formation in this test system was inhibited by citrate amd EDTA. FeCl/ sub 3/ and low concemtratioms of ascorbic acid were catalytic. Whole-body irradiatiom destroyed the antioxidant activity of the mucosa but had no effect on that of other tissues. The mucosa from irradiated animals catalyzed peroxide formation in incubated methyl linolemate emulsions as well as in the liver homogenate. When tested by the inhibition of melanin formation, the antioxidant activity of irradiated mucosa was somewhat less than that of the unirradiated controls, but it never catalyzed this reaction. (auth)
- Research Organization:
- Duke Univ., Durham, N.C.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-13-009642
- OSTI ID:
- 4289906
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Vol. Vol: 10
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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Related Subjects
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BODY
BONE MARROW
BRAIN
CATALYSIS
CHEMICAL REACTIONS
CITRIC ACID
EDTA
FLUIDS
GONADS
HOMOGENEOUS REACTORS
INTESTINE
IRON CHLORIDES
LINOLEIC ACID
MEASURED VALUES
MELANIN
ORGANIC ACIDS
OXIDATION
OXIDES
PEROXIDES
RADIATION EFFECTS
RATS
SALTS
SPLEEN
TESTES
TISSUES
VITAMIN C
VITAMINS
X RADIATION