Identification of the Immune System Responsible for the Specificity of Actively Acquired Tolerance in Mice

Journal Article · Fri Mar 01 04:00:00 EST 1963 · Proceedings of the National Academy of Sciences of the United States of America

DOI:https://doi.org/10.1073/pnas.49.3.281· OSTI ID:4702711

Doria, G.

Tolerance to CBA/Cum skin was induced in C3H/Anf Cum mice by neonatal injection of CBA/Cum spleen cells. The tolerant status of these mice was a specific one, for they were able to produce a normal amount of agglutinins against a challenge dose of rat RBC. The immune system responsible for the specificity of tolerance in these mice was identified to be of host type. No immune activity of donor cells against rat RBC could be detected, whereas donor type antigenicity was found in the spleen of the tolerant mice. On the basis of these findings it was proposed that the definition of tolerance given for the whole animal could also be applied to its immune system.

• Research Organization: Oak Ridge National Lab., Tenn.
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-028775
• OSTI ID: 4702711
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America, Journal Name: Proceedings of the National Academy of Sciences of the United States of America Journal Issue: 3 Vol. 49; ISSN 0027-8424
• Publisher: National Academy of Sciences, Washington, DC (United States)
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGGLUTININS
ANIMAL CELLS
ANTIBODIES
ANTIGENS
BIOLOGY AND MEDICINE
IMMUNITY
MICE
RATS
SENSITIVITY
SKIN
SPLEEN
TRANSPLANTS