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A CYTOLOGICAL ANALYSIS OF THE EFFECT OF HIGH-ENERGY PROTONS. 1. CELL DEGENERATION AND MITOTIC ACTIVITY OF BONE MARROW IN MICE SUBJECTED TO WHOLE-BODY IRRADIATION WITH 660 MEV PROTONS (in Russian)

Journal Article · · Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.)
OSTI ID:4694981
;
White mice were subjected to 660 Mev proton doses of 800 and 1000 rads. The mice were killed at various times after the irradiation, and a total of 3000 to 5000 cells from the bone marrow were examined in order to determine the number of degenerate cells, and the mitotic activity of the cells. With a dose of 800 rads, the number of degenerate cells is 2% one hour after the irradiation, and reached a maximum of 5% three hours after the irradiation. The number of degenerate cells then decreases to a normal value two days after the irradiation. With a dose of 1000 rads, the number of damaged cells attains a maximum of 8.5% in three to five hours after the irradation. No mitoses were observed for the first three hours after irradiation. The mitotic activity then began to rise, and attained a normal vaiue after two days. A comparative experiment was run by giving the mice a Co/sup 60/ dose of 800 rads. lt was found that the number of degenerate cells from the Co/sup 60/ irradiation is a factor of at least two greater than the number of degenerate cells observed by proton irradiation at a dose of 800 rads. The relative biological effectiveness of the protons is 0.3, when compared to the effectiveness of the gamma rays. (TTT)
Research Organization:
Inst. of Industrial Hygiene and Prophylaxis, Academy of Medical Sciences, Moscow
NSA Number:
NSA-17-030366
OSTI ID:
4694981
Journal Information:
Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 3; ISSN RADOA
Country of Publication:
Country unknown/Code not available
Language:
Russian

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Related Subjects

BIOLOGY AND MEDICINE
BODY
BONE MARROW
COBALT 60
CYTOLOGY
DEGENERATION
GAMMA RADIATION
MICE
MITOSIS
PROTON BEAMS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIOBIOLOGY
RBE
STANDARDS
VARIATIONS