THE ELIMINATION OF RADIOACTIVE CERIUM FROM THE BODY WITH THE USE OF TRIETHYLENE-TETRAMINEHEXACETIC ACID (TTHA), AND TETRA-ETHYLENEPENTAMINEHEPTACETIC ACID (TPHA)

Journal Article · Mon Dec 31 23:00:00 EST 1962 · Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.)

OSTI ID:4688322

Torchinskaya, O L; Razumovskii, N O; Yashunskii, V G; Balabukha, V S; Ushakova, V F

The compound diethylenetriaminepentacetic acid (DTPA) had been shown to be more effective than EDTA in removing rare earths and heavy elements from the body. The derivatives triethylenetetraminehexacetic acid (TTHA) and tetraethylenepentamineheptacetic acid (TPHA) were synthesized and compared with DTPA for effectiveness. When injected intraperitoneally as a Ce/sup 144/ complex (dosage 0.1 mu c of Ce/sup 144//g and 100 mu -mols of complexing agent per injection) in white rats, it was found that the DTPA and TTHA complexes were the most stable in the body. After injection of the Ce/sup 144/ complex, it was found that 2.9% of the activity remains in the bones with DTPA, 4.65% with TTHA, and 77.9% with TPHA, as compared to the activity content in the controls. The kidneys showed activity of 30% of the control for all three complexes. If the complexing agent is introduced within 30 minutes before introduction of Ce/sup 144/ into the body, DTPA and TTHA are both effective in eliminating Ce/sup 144/ from the body, but the effect is considerably less, if the complexing agent is introduced 6 hours before introduction of the activity. If the complexing agent is injected as a series of 12 weekly injections two weeks after introducing the activity, the residual activity in the liver is 4.3% with DTPA, and 6.1% with TTHA, as compared to the controls. TTHA and DTPA are more effective than TPHA. (TTT)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-17-030264
• OSTI ID: 4688322
• Journal Information: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 3; ISSN RADOA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

ACETIC ACID
AMINES
BIOLOGY AND MEDICINE
BODY
BONES
CERIUM 144
CHELATES
CHEMICAL REACTIONS
COMPLEXES
DECONTAMINATION
DENSITY
DTPA
EDTA
EFFICIENCY
ELEMENTS
ETHYLENE
KIDNEYS
LIVER
METABOLISM
MOLECULES
ORGANIC ACIDS
QUANTITY RATIO
RADIATION DOSES
RADIOACTIVITY
RARE EARTHS
RATS
STABILITY
VARIATIONS
WEIGHT