Notes on the Problems of the Transplantation of Kidneys in Dogs

Journal Article · Tue Jan 01 04:00:00 EST 1963 · Transplantation (Baltimore)

DOI:https://doi.org/10.1097/00007890-196301030-00016· OSTI ID:4686693

Puza, A.; Drahovsky, V.; Neubauer, E.; Klime, M.; Kňazovick, M.

In a group of 29 mongrel dogs kidney homotransplantation was performed. In five dogs an autograft was performed to check the suitability of the surgical technique. In the remaining 24 dogs kidney homografts were carried out, Five dogs served as controls; in these animals the functioning of the homografted kidney stopped after 8 days on the average, In 12 animals an attempt at the induction of immunological tolerance by exsanguinotransfusion, whole-body irradiation and 6-MP-administration was made. Induction of immunological tolerance by total exsanguinotransfusion immediately after birth may render possible a successful homograft even in adult life. The transplanted organ then exhibits a permanent take and takes over the function of the recipient's removed kidneys. One dog is alive with its single kidney homograft after almost two years. 6-MP administration may lead to such a degree of induced tolerance that the function of a kidney homograft is prolonged by a factor of two to three. Whole-body irradiation within a range of 400 rad (Co⁶⁰ source) does not significantly prolong homograft survival.

• Research Organization: Safarik Univ., Kosice, Czechoslovakia
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-030379
• OSTI ID: 4686693
• Journal Information: Transplantation (Baltimore), Journal Name: Transplantation (Baltimore) Journal Issue: 3 Vol. 1; ISSN 0041-1337
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
BLOOD
BODY
CHEMICALS
COBALT 60
DOGS
GAMMA RADIATION
IMMUNITY
KIDNEYS
PHYSIOLOGY
RADIATION DOSES
RADIATION EFFECTS
SENSITIVITY
SURGERY
SURVIVAL TIME
TRANSFUSIONS
TRANSPLANTS
VARIATIONS