RENAL TRANSPLANTATION IN AZOTEMIC DOGS

Journal Article · Mon Feb 01 04:00:00 EST 1960 · Surgery (U.S.)

OSTI ID:4136566

Mannick, J A; Powers, J H; Mithoefer, J; Ferrebee, J W

A method for producing chronic azotemia or uremia in dogs is described. One kidney is removed and the other damaged by perfusion with the 6- aminonucleoside of Puromycin. Dogs with chronic azotemia were found to tolerate homografts of kidney for longer periods than do normal dogs (15 to 21 days in 4 azotemic dogs as compared with a rejection time of 7 days in 4 normal dogs). Three azotemic dogs were subjected to total body irradiation for the purpose of reducing immune responses. The radiation tolerance of these dogs did not seem different from that of normal dogs. In one of these animals, after 1,300 r of whole body exposure, a kidney homograft inserted on the second day after irradiation functioned normally until death of the animal from marrow aplasia on day 15. From these preliminary observations it is concluded that the potentiation of kidney homograft survival that is known to follow nitrogen retention and whole body irradiation may be studied satisfactorily on an experimental basis in the dog. (auth)

• Research Organization: Mary Imogene Bassett Hospital, Cooperstown, N.Y.
• NSA Number: NSA-14-025348
• OSTI ID: 4136566
• Journal Information: Surgery (U.S.), Journal Name: Surgery (U.S.) Vol. Vol: 47; ISSN SURGA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD
BODY
DOGS
IMMUNITY
IRRADIATION
KIDNEYS
NITROGEN
QUANTITY RATIO
RADIATION EFFECTS
TRANSPLANTS