EFFECTIVENESS OF THE HIGH-MOLECULAR DNA IN THE TREATMENT OF ACUTE RADIATION SICKNESS

Journal Article · Mon Dec 31 23:00:00 EST 1962 · Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.)

OSTI ID:4686296

Libinzon, R E; Konstantinova, V V; Muksinova, K N; Popova, T G; Rogaeheva, S A

Although the therapeutic action of the bone marrow in the treatment of irradiated animals is mostly due to the repopulation of the donor's cells in the body of the recipient, it is possible that the decomposition products of the introduced cells stimulate the blood formation. It was noted that during the first days after the introduction of the bone marrow suspensions, a stimulating action was exerted on the reticular cells of the recipient's bone marrow. This effect might be due to desoxvnucleoproteid or to DNA of the animal's bone marrow cells, the therapeutic effect of DNA introduced into various tissues of animals affected by radiation sickness was investigated. Rats of both sexes were exposed to 1000 r of gamma radiation of Co/sup 60/ at a dose rate of 20 r/min, administering within 24 hours after the exposure 3 to 6 mg of specially prepared, highmolecular DNA in 1 to 2 ml of physiological solution intravenously or intraperitoneally; unirradiated but injected animals served as controls. Results indicated that the isologous, high-molecular preparation had a high therapeutic effectiveness. The survival rate jumped from 2 to 13% level in the control group to 40 to 58%. Factors affecting the DNA preparation reduced its effectiveness. The effect is probably due to the phagocytosis of the DNA par ticles and Noneof the desoxyribNoneoNonenucNoneleoNoneproteid by the reticular cells of the blood. (TTT)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-17-030417
• OSTI ID: 4686296
• Journal Information: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 3; ISSN RADOA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

ANIMALS
ATOMS
BIOLOGY AND MEDICINE
BLOOD CELLS
BLOOD FORMATION
BLOOD VESSELS
BODY
BONE MARROW
COBALT 60
CYTOLOGY
DECAY
DECOMPOSITION
DNA
EFFICIENCY
ELECTRONS
ENERGY LEVELS
ERRORS
EXCITATION
GAMMA RADIATION
HELIUM
LIFETIME
MEASURED VALUES
MEDICINE
MOLECULES
NUCLEIC ACIDS
PHAGOCYTOSIS
PHYSIOLOGY
PLANNING
PROTEINS
PULSE ANALYZERS
PULSES
QUANTITY RATIO
RADIATION DOSES
RADIATION PROTECTION
RADIATION SICKNESS
RATS
RETICULAR CELLS
SEX
SODIUM CHLORIDES
SOLUTIONS
SURVIVAL TIME
SUSPENSIONS
TISSUES
TRANSPLANTS
VARIATIONS