THE SIGNIFICANCE OF SENSITIZATION BY TISSUE ANTIGENS IN REACTIVITY CHANGES OF AN IRRADIATED ORGANISM. EXPERIMENTAL HOMOSENSITIZATION AND ITS EFFECT ON IMMUNOGENESIS

Journal Article · Tue Jan 01 04:00:00 EST 1963 · Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.)

OSTI ID:4686165

Klemparskaya, N N; Shikhodyrov, V V

Homosensitization can be induced in a healthy animal by injecting a suspension of tissue taken from an irradi ated animal. Pathological symptoms characteristic of radiation sickness such as internal bleeding and change in tissue penetrability can lead to the death of the animal two or three weeks after sensitization. Due to the competition between antigens, the introduction of a bacterial antigen after sensitization results in a decrease in severity of the pathological symptoms. Thus, experiments on rabbits show that the introduction of a microbial antigen during the first week after sensitization by irradiated tissue can decrease the severity of pathological symptoms such as a loss in weight and the development of leucocytosis. Experiments on guinea pigs gave similar results. In this case, inoculation with the bacterial antigen 15 days after sensitization resulted in a decrease of the number of cases of leucopenia by a factor of 7, as compared to the sensitized guinea pigs which were not treated with bacterial antigen. A histological study of tissue from sensitized white mice shows the presence of protein dystrophy of the parenchymal cells, an increase in the number of Kupffer cells, a decrease in the number of lymphocytes, bleeding in lung tissue, and edema of the alveolar membrane. The best results in mitigating the pathological symptoms of sensitization in white mice were obtained by inoculating the mice with the microbial vaccine before sensitization. (TTT)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-17-030422
• OSTI ID: 4686165
• Journal Information: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 3; ISSN RADOA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

ANTIGENS
BACTERIA
BIOLOGY AND MEDICINE
CALCIUM FLUORIDES
CRYSTALS
CYTOLOGY
DIFFUSION
DISEASES
EDEMA
FREQUENCY
GUINEA PIGS
HEMORRHAGE
IMMUNITY
IMPURITIES
IONS
KUPFFER CELLS
LEUCOCYTES
LUMINESCENCE
LUNGS
MICE
PROTEINS
QUANTITY RATIO
RABBITS
RADIATION SICKNESS
SPECTRA
SURVIVAL TIME
SUSPENSIONS
TEMPERATURE
TISSUES
TRANSPLANTS
URANIUM
VARIATIONS
WEIGHT