I$sup 131$ ACCUMULATION BY THE LACTATING RAT MAMMARY GLAND
The mammary glands of lactating rats fed a low-iodine diet accumulated 50% of an injected I/sup 131/ dose or 5 times as much as the thyroid gland and twice as much as excreted by the kidneys in 17 to 24 hr. Rats that accumulated greater amounts of I/sup 131/ in their mammary glands had significantly lesser thyroidal I/sup 131/ uptakes. KClO/sub 4/ and methimazole significantly reduced accumulation of I/sup 131/ in milk, KClO/sub 4/ being the more potent. Methimazole acted primarily in reducing the binding of I/sup 131/ to milk protein. The concentration of I/sup 131/ in milk, trichloroacetic acid-precipitable I/sup 131/ in milk and in plasma, and ratio of milk I/sup 131/ to plasma I/sup 131/ were significantly reduced by the addition of iodide to the diet. The amount of I/sup 131/ in the milk was not correlated with the amount of milk secreted. Exogenous thyroxin inhibited thyroidal I/sup 131/ uptake but did not influence accumulation of I/sup 131/ by the mammary gland. Injection of thyrotrophin restored thyroidal uptake of I/sup 131/ but did not affect accumulation of I/sup 131/ by the mammary gland. (auth)
- Research Organization:
- Univ. of Tennessee, Memphis
- NSA Number:
- NSA-17-024851
- OSTI ID:
- 4680662
- Journal Information:
- American Journal of Physiology (U.S.), Journal Name: American Journal of Physiology (U.S.) Vol. Vol: 204; ISSN AJPHA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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