Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Comparison of L-thyroxine and a saturated solution of potassium iodide in preventing damage to the thyroid following iodine-131-labeled antibody injection

Journal Article · · NCI Monogr.; (United States)
OSTI ID:6517478
; ; ; ; ; ;

Following injection of radioiodinated antibodies in diagnostic amounts, there is variable uptake of radioiodine by the thyroid. Unless preventive steps are taken, radiation damage to the gland may occur. We have evaluated the role of L-thyroxine and a saturated solution of potassium iodide (SSKI) in preventing radiation damage to the thyroid glands of Sprague-Dawley adult male rats by measuring DNA strand breakage by the nucleoid sedimentation gradient method. Pretreatment with SSKI reduced DNA damage and also reduced /sup 131/I accumulation in the thyroid. Pretreatment with L-thyroxine also reduced DNA damage without significantly reducing /sup 131/I accumulation in the thyroid. The possible mechanisms of action of L-thyroxine and SSKI in preventing radiation damage to the thyroid are addressed.

Research Organization:
Veterans Administration Medical Center, Seattle, WA
OSTI ID:
6517478
Journal Information:
NCI Monogr.; (United States), Journal Name: NCI Monogr.; (United States) Vol. 3; ISSN NCIME
Country of Publication:
United States
Language:
English

Similar Records

The concentration of radioactive iodine in the thyroid lymph, thyroid venous blood and peripheral blood of primates
Journal Article · Thu Oct 31 23:00:00 EST 1963 · Journal of Physiology · OSTI ID:4059328
ESTIMATION OF RADIATION DOSAGE DELIVERED BY A SINGLE MASSIVE INJECTION OF I$sup 131$ IN THE RAT
Journal Article · Tue Jan 31 23:00:00 EST 1961 · Radiation Research · OSTI ID:4094230
LOCALIZATION OF PROTEIN-BOUND RADIOACTIVE IODINE IN RAT THYROID GLANDS LABELLED WITH $sup 125$I OR $sup 131$I
Journal Article · Fri Oct 30 23:00:00 EST 1964 · Biochemical Journal (England) · OSTI ID:4059809

Related Subjects

560161* -- Radionuclide Effects
Kinetics
& Toxicology-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOXYLIC ACIDS
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DNA
ENDOCRINE GLANDS
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
GLANDS
HALIDES
HALOGEN COMPOUNDS
HORMONES
INJURIES
INORGANIC PHOSPHORS
INTERMEDIATE MASS NUCLEI
IODIDES
IODINE 131
IODINE COMPOUNDS
IODINE ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
NUCLEIC ACIDS
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PEPTIDE HORMONES
PHOSPHORS
POTASSIUM COMPOUNDS
POTASSIUM IODIDES
RADIATION EFFECTS
RADIATION INJURIES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
SIDE EFFECTS
STRAND BREAKS
THYROID
THYROID HORMONES
THYROXINE
UPTAKE
VERTEBRATES