Sensitivity of Irradiated Mice to Bacterial Endotoxin

Journal Article · Mon Jul 01 04:00:00 EDT 1963 · Experimental Biology and Medicine

DOI:https://doi.org/10.3181/00379727-113-28489· OSTI ID:4666151

Smith, W. W.; Alderman, I. M.; Schneider, C.; Cornfield, J.

Exposure to radiation, especially in the lethal range, caused a marked increase in sensitivity of mice to S. typhosa endotoxin. This was most pronounced on the third day after irradiation. At that time the endotoxin LD/sub 50/ in mice given 1000 rads was 0.5 mu g compared to a control value of 480 mu g per 20 g mouse. Shielding the hind legs was without effect on endotoxin LD/sub 50/ (2.5 mu g for 850 r, 200 Kv x rays). Shielding the back, including the adrenals, was partially effective (LD/sub 50/, 55 mu g). Treatment with cortisone had an effect comparable to that of shielding the back. Shielding the front of the animal, including practically all of the intestinal tract, was very effective in spite of the fact that the adrenals were irradiated (LD/sub 50/, 410 mu g). Shielding a small portion of the abdomen was also quite effective in reducing endotoxin sensitivity in the irradiated inice (LD/sub 50/, 155 mu g).

• Research Organization: National Cancer Inst.; and National Heart Inst., Bethesda, Md.
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-031921
• OSTI ID: 4666151
• Journal Information: Experimental Biology and Medicine, Journal Name: Experimental Biology and Medicine Journal Issue: 3 Vol. 113; ISSN 1535-3702
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ADRENAL GLANDS
BACTERIA
BIOLOGY AND MEDICINE
CORTISONE
DISTRIBUTION
EFFICIENCY
ENDOTOXINS
HORMONES
IMMUNITY
INTESTINE
LETHAL DOSE
MICE
PROTEINS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
SALMONELLA
SENSITIVITY
SHIELDING
TOXICITY
VARIATIONS