Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins

Journal Article · Mon Jul 01 04:00:00 EDT 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0343· OSTI ID:466039

Doyle, J; Stubbs, L ^[1]; Hoffman, S ^[2]

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1. Oak Ridge National Lab., TN (United States)
2. Lawrence Livermore National Lab., CA (United States); and others

RFX transcription factors constitute a highly conserved family of site-specific DNA binding proteins involved in the expression of a variety of cellular and viral genes, including major histocompatibility complex class II genes and genes in human hepatitis B virus. Five members of the RFX gene family have been isolated from human and mouse, and all share a highly characteristic DNA binding domain that is distinct from other known DNA binding motifs. The human RFX1 and RFX2 genes have been assigned by in situ hybridization to chromosome 19p13.1 and 19p13.3, respectively. In this paper, we present data that localize RFX1 and RFX2 precisely within the detailed physical map of human chromosome 19 and genetic data that assign Rfx1 and Rfx2 to homologous regions of mouse chromosomes 8 and 17, respectively. These data define the established relationships between these homologous mouse and human regions in further detail and provide new tools for linking cloned genes to phenotypes in both species. 26 ref., 2 figs.

• DOE Contract Number: AC05-84OR21400; W-7405-ENG-48
• OSTI ID: 466039
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 35; ISSN 0888-7543; ISSN GNMCEP
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BIOLOGICAL EVOLUTION
BIOLOGICAL MARKERS
CHROMOSOMES
CONTIGS
DNA SEQUENCING
DNA-CLONING
GENE REGULATION
GENETIC MAPPING
HEPATITIS
HISTOCOMPATIBILITY COMPLEX
HUMAN CHROMOSOME 19
IN-SITU HYBRIDIZATION
MAN
MICE
PHENOTYPE
PROBES
PROTEINS
TRANSCRIPTION FACTORS